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qFlamma® Black01 Hydrazide
Catalog No. QWH1001
| PACKING UNIT | price |
Lead time |
|---|---|---|
| 1 mg | $121.00 | |
| 5 mg | $441.00 | |
| 25 mg | $882.00 |
Description
qFlamma® Black01 Hydrazide
is an aldehyde and ketone reactive universal dark quencher that the absorption
range covers from 400 to 800 nm with no native fluorescence. Black01
quencher displays high absorption coefficient, superb stability and
aqueous solubility. Hydrazides can label aldehyde and
ketone through reductive amination reaction to form an imine linkage. The main
labeling target for hydrazides are reducing sugars on biomolecules, and prior
to conjugation, primary and secondary alcohols on polysaccharide and
glycoprotein should be oxidized to corresponding aldehyde and ketone. We offer qFlamma® Black01
Hydrazide to label biomolecules bearing aldehyde or ketone for designing probes
consisting of spectrally paired fluorophore and quencher.
Citation & Reference
1. Arnaud Chevalier. Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chemistry 19.5 (2013): 1686-99.
2. Arnaud Chevalier. Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes. Org. Lett 2013 15.23 (2013): 6082–6085.
3. Arnaud Chevalier. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Letters 55.50 (2014): 6759-6763.
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