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qFlamma® Black01 Maleimide
Catalog No. QWM1001
| PACKING UNIT | price |
Lead time |
|---|---|---|
| 1 mg | $121.00 | |
| 5 mg | $441.00 | |
| 25 mg | $882.00 |
Description
qFlamma® Black01 Maleimide is a thiol reactive universal dark quencher that the range of absorption covers from 400 to 800 nm with no native fluorescence. Black01 quencher displays high absorption coefficient, superb stability and aqueous solubility. Maleimides selectively label thiols of probes, peptide or protein via 1,4-addition pathway, without interacting with amines, to form thioether linkage. Maleimides apparently do not react with methionine, histidine or tyrosine, but they might react with primary amines under strong basic environment. We offer qFlamma® Black01 maleimide as a universal dark quencher in the construction of a variety of hybridization and custom-synthesized activatable probes for multiplexed bio-analysis, PCR, nucleic acid hybridization, etc.
Citation & Reference
1. Cho H-J, Injectable single-component peptide depot: Autonomously rechargeable tumor photosensitization for repeated photodynamic therapy. ACS Nano. 2020 Nov 11;14(11):15793–805.
2. Cho H-J, Tumor Microenvironment-responsive fluorogenic nanoprobe for ratiometric dual-channel imaging of lymph node metastasis. Colloids and Surfaces B: Biointerfaces. 2019 Jul;179:9–16.
3. Arnaud Chevalier. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Letters 55.50 (2014): 6759-6763.
4. Arnaud Chevalier. Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chemistry 19.5 (2013): 1686-99.
5. Arnaud Chevalier. Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes. Org. Lett 2013 15.23 (2013): 6082–6085.
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