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qFlamma® Black01 Sulfo-NHS ester
Catalog No. QWSN1001
| PACKING UNIT | price |
Lead time |
|---|---|---|
| 1 mg | $121.00 | |
| 5 mg | $441.00 | |
| 25 mg | $882.00 |
Description
qFlamma® Black01 Sulfo-NHS ester is an amine reactive form of universal dark quencher that the range of absorption covers from 400 to 800 nm with no native fluorescence. Black01 quencher displays high absorption coefficient, superb stability and aqueous solubility. Sulfo-NHS esters have higher water solubility than NHS esters, thus they do not need organic co-solvent and readily react with amino groups of probes, peptides or the amine terminus of nucleotides to form a chemically stable amide bond between the quencher and the biomolecule. We offer qFlamma® Black01 Sulfo-NHS ester as a universal quencher in the construction of a variety of hybridization and custom-synthesized activatable probes for multiplexed bio-analysis, PCR, nucleic acid hybridization, etc.
Citation & Reference
1. Cho H-J, Injectable single-component peptide depot: Autonomously rechargeable tumor photosensitization for repeated photodynamic therapy. ACS Nano. 2020 Nov 11;14(11):15793–805.
2. Cho H-J, Tumor Microenvironment-responsive fluorogenic nanoprobe for ratiometric dual-channel imaging of lymph node metastasis. Colloids and Surfaces B: Biointerfaces. 2019 Jul;179:9–16.
3. Arnaud Chevalier. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Letters 55.50 (2014): 6759-6763.
4. Arnaud Chevalier. Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chemistry 19.5 (2013): 1686-99.
5. Arnaud Chevalier. Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes. Org. Lett 2013 15.23 (2013): 6082–6085.
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