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Flamma® Fluors Isothiocyanate
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Flamma® 749 Isothiocyanate
- Flamma® Fluors NHS ester
- Flamma® Fluors Sulfo-NHS ester
- Flamma® Fluors Vinylsulfone
- Flamma® Fluors Isothiocyanate
- Flamma® Fluors Maleimide
- Flamma® Fluors Hydrazide
- Flamma® Fluors Dichlorotriazine
- Flamma® Fluors Carboxylic acid
- Flamma® Fluors Amine
- Flamma® Fluors Thiol
- Flamma® Fluors Alkyne
- Flamma® Fluors PEG4-Alkyne
- Flamma® Fluors ADIBO
- Flamma® Fluors Azide
Flamma® 749 Isothiocyanate
Catalog No. PWI1308
| PACKING UNIT | price |
Lead time |
|---|---|---|
| 1 mg | $555.00 | |
| 5 mg | $1,914.00 | |
| 25 mg | $7,106.00 |
Description
Flamma® Fluors 749 Isothiocyanate is a reactive form of near infrared (NIR) fluorescent dye induced from cyanine structure and used to generate a stable fluorescence signal in bioimaging. The maxima of Ex/Em values are at 749/774 nm, similar to that of Alexa 750, Cy7, IRDye 750 and DyLight 755. Flamma 749 might be excited using 750 nm laser line or dye-pumped laser excitation and the emission occurs at biological tissue permeable NIR region. Flamma 749-conjugated primary and secondary antibody are used as molecular probes for in vitro imaging and other fluorescence detection methods. Isothiocyanates are moderately reactive but quite stable in water and most organic solvents. Isothiocyanates react to primary amine to form reasonably stable thiourea linkage. Whereas labeling of protein with NHS esters can typically be done at pH 8.3, conjugation for isothiocyanates usually require pH above 9. We offer Flamma Fluors 749 isothiocyanate for labeling of antibodies, peptides, proteins, ligands and in vivo NIR imaging.
Citation & Reference
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9. Zhu, Lei. Real-time monitoring of caspase cascade activation in living cells. Journal of controlled release 163.1 (2012): 55-62.
10. Yoon, Hong Yeol. Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting. Journal of Controlled Release 172.3 (2013): 653-661.
11. Yhee, Ji Young. Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance. Journal of Controlled Release 198 (2015): 1-9.
12. Park, Jin Woo. Wide-Ranged Fluorescent Molecular Weight Size Markers for Electrophoresis. Bulletin of the Korean Chemical Society 34.1 (2013): 29-30.
13. Huang, Xinglu. Multiplex Imaging of an Intracellular Proteolytic Cascade by using a Broad?Spectrum Nanoquencher. Angewandte Chemie International Edition 51.7 (2012): 1625-1630.
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